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Correlation of Body Weight with Plasma Atherogenic Index in Obese Rats Given Black Garlic

Authors

  • Prima Adelin Universitas Baiturrahmah
  • Relly Angelica Putriza Universitas Baiturrahmah
  • Haves Ashan Universitas Baiturrahmah
  • Dian Puspita Universitas Baiturrahmah
  • Rifkind Rifkind Universitas Baiturrahmah
  • Letvimona Letvimona Universitas Baiturrahmah
Published October 16, 2025 pp. 1-7 doi.org/10.62872/o.v2i5.233 CC BY-SA 4.0
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Abstract

Obesity triggers changes in blood lipid profiles and increases the risk of atherosclerosis, one of which is measured by the plasma atherogenic index (IAP). Black garlic contains active compounds such as allicin and S-allylcysteine, which are known to have hypolipidemic effects. This study aims to determine the relationship between changes in body weight and IAP values ​​in obese rat models given black garlic extract. This study was a pre-post test experiment with a control, using 28 male Sprague Dawley rats divided into 4 groups: negative control (normal diet), positive control (high-fat and fructose diet), treatment dose 1 (black garlic 1.6 ml/day), and treatment dose 2 (black garlic 0.8 ml/day). Measurements of body weight and triglyceride and HDL levels were carried out before and after the intervention. The results showed that administration of black garlic caused significant changes in body weight and IAP values ​​(p<0.05), but the correlation between changes in body weight and IAP values ​​was not significant (p>0.05). In conclusion, there was no significant relationship between changes in body weight and IAP values ​​in obese mice given black garlic.

Keywords

black garlicplasma atherogenic indexobesity

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References

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Copyright (c) 2025 Prima Adelin, Relly Angelica Putriza, Haves Ashan, Dian Puspita, Rifkind Rifkind , Letvimona Letvimona (Author) · CC BY-SA 4.0

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